Related references
Note: Only part of the references are listed.Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae
Michaela Cutova et al.
GENOMICS (2020)
Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase
Jun Tan et al.
FEBS LETTERS (2020)
On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability
Alexandra N. Khristich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Emerging roles for R-loop structures in the management of topological stress
Frederic Chedin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells
Jussara Amato et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
DNA Junction Ligands Trigger DNA Damage and Are Synthetic Lethal with DNA Repair Inhibitors in Cancer Cells
Katerina Duskova et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Regulatory R-loops as facilitators of gene expression and genome stability
Christof Niehrs et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?
Alice Bradbury et al.
PHARMACOLOGY & THERAPEUTICS (2020)
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
Peter M. Bruno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes
Sreejana Ray et al.
ACS CHEMICAL BIOLOGY (2020)
Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons
Jose F. Moruno-Manchon et al.
ELIFE (2020)
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Elaine Sanij et al.
NATURE COMMUNICATIONS (2020)
The regulation and functions of DNA and RNA G-quadruplexes
Dhaval Varshney et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
A Genetic Map of the Response to DNA Damage in Human Cells
Michele Olivieri et al.
CELL (2020)
Nucleolar RNA polymerase II drives ribosome biogenesis
Karan J. Abraham et al.
NATURE (2020)
Single-molecule visualization of DNA G-quadruplex formation in live cells
Marco Di Antonio et al.
NATURE CHEMISTRY (2020)
Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism
Diana C. Odermatt et al.
PLOS GENETICS (2020)
ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
Sebastien Britton et al.
NUCLEIC ACIDS RESEARCH (2020)
RPA and Pif1 cooperate to remove G-rich structures at both leading and lagging strand
Laetitia Maestroni et al.
CELL STRESS (2020)
Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome
Federica Raguseo et al.
CHEMICAL COMMUNICATIONS (2020)
The Structure and Function of DNA G-Quadruplexes
Jochen Spiegel et al.
TRENDS IN CHEMISTRY (2020)
R-Loops as Cellular Regulators and Genomic Threats
Madzia P. Crossley et al.
MOLECULAR CELL (2019)
Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase
Saba Dehghani-Tafti et al.
NUCLEIC ACIDS RESEARCH (2019)
Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
Jennifer Beauvarlet et al.
NUCLEIC ACIDS RESEARCH (2019)
Whole genome experimental maps of DNA G-quadruplexes in multiple species
Giovanni Marsico et al.
NUCLEIC ACIDS RESEARCH (2019)
G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
Yuxiang Wang et al.
NATURE COMMUNICATIONS (2019)
Holding All the Cards-How Fanconi Anemia Proteins Deal with Replication Stress and Preserve Genomic Stability
Arindam Datta et al.
GENES (2019)
Transcription-mediated replication hindrance: a major driver of genome instability
Belen Gomez-Gonzalez et al.
GENES & DEVELOPMENT (2019)
Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays
Katerina Duskova et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
High-resolution, strand-specific R-loop mapping via S9.6-based DNA-RNA immunoprecipitation and high-throughput sequencing
Lionel A. Sanz et al.
NATURE PROTOCOLS (2019)
Tools To Live By: Bacterial DNA Structures Illuminate Cancer
Jun Xia et al.
TRENDS IN GENETICS (2019)
PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers
Man Yee T. Keung et al.
JOURNAL OF CLINICAL MEDICINE (2019)
Targeting Topoisomerase I in the Era of Precision Medicine
Anish Thomas et al.
CLINICAL CANCER RESEARCH (2019)
Regulation of replication fork speed: Mechanisms and impact on genomic stability
Joanna Maria Merchut-Maya et al.
DNA REPAIR (2019)
Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?
Nadine Puget et al.
DNA REPAIR (2019)
G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells
F. Berardinelli et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)
Fe4IIL4 Tetrahedron Binds to Nonpaired DNA Bases
Jinbo Zhu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
DNA double-strand break repair-pathway choice in somatic mammalian cells
Ralph Scully et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Involvement of G-quadruplex regions in mammalian replication origin activity
Paulina Prorok et al.
NATURE COMMUNICATIONS (2019)
Genetic interactions of G-quadruplexes in humans
Katherine G. Zyner et al.
ELIFE (2019)
Mission Possible: Advances in MYC Therapeutic Targeting in Cancer
Brittany L. Allen-Petersen et al.
BIODRUGS (2019)
The Interplay between G-quadruplex and Transcription
Nayun Kim
CURRENT MEDICINAL CHEMISTRY (2019)
Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes
Tracy M. Bryan
MOLECULES (2019)
Chromosome instability syndromes
A. Malcolm R. Taylor et al.
NATURE REVIEWS DISEASE PRIMERS (2019)
Applications of guanine quartets in nanotechnology and chemical biology
Loic Stefan et al.
NATURE REVIEWS CHEMISTRY (2019)
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019)
Concepcion Sanchez-Martinez et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
Genetic determinants of cellular addiction to DNA polymerase theta
Wanjuan Feng et al.
NATURE COMMUNICATIONS (2019)
Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo
Peter Lansdorp et al.
GENES (2019)
Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand-DNA Adducts
Coralie Caron et al.
CHEMISTRY-A EUROPEAN JOURNAL (2019)
The role of fork stalling and DNA structures in causing chromosome fragility
Simran Kaushal et al.
GENES CHROMOSOMES & CANCER (2019)
Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
Cornelia Meisenberg et al.
MOLECULAR CELL (2019)
State-of-the-art strategies for targeting the DNA damage response in cancer
Patrick G. Pilie et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2019)
Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function
Lionel Gellon et al.
NUCLEIC ACIDS RESEARCH (2019)
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
Alessio De Magis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy
Pamela Munster et al.
CANCER MANAGEMENT AND RESEARCH (2019)
ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures
Shibo Li et al.
ISCIENCE (2019)
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Yuan Cheng et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)
BRCA Genes: The Role in Genome Stability, Cancer Sternness and Therapy Resistance
Ielizaveta Gorodetska et al.
JOURNAL OF CANCER (2019)
Mechanistic enzymology in drug discovery: a fresh perspective
Geoffrey A. Holdgate et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro
Ludivine Guyon et al.
NUCLEIC ACIDS RESEARCH (2018)
Topoisomerases as anticancer targets
Justine L. Delgado et al.
BIOCHEMICAL JOURNAL (2018)
Homologous recombination and the repair of DNA double-strand breaks
William Douglass Wright et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
Niek van Wietmarschen et al.
NATURE COMMUNICATIONS (2018)
The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair
Aleem Syed et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)
Restored replication fork stabilization, a mechanism of PARP inhibitor resistance, can be overcome by cell cycle checkpoint inhibition
Brittany Haynes et al.
CANCER TREATMENT REVIEWS (2018)
The pendulum of the Ku-Ku clock
Atsushi Shibata et al.
DNA REPAIR (2018)
The shieldin complex mediates 53BP1-dependent DNA repair
Sylvie M. Noordermeer et al.
NATURE (2018)
The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures
Sonia Jimeno et al.
CELL REPORTS (2018)
Visualizing biologically active small molecules in cells using click chemistry
Tatiana Caneque et al.
NATURE REVIEWS CHEMISTRY (2018)
PARPs in genome stability and signal transduction: implications for cancer therapy
Luca Palazzo et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2018)
Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives
Jessica Marinello et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition
Nishita Shastri et al.
MOLECULAR CELL (2018)
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery
Peter Tonzi et al.
ELIFE (2018)
The Emerging Role of Cohesin in the DNA Damage Response
Ireneusz Litwin et al.
GENES (2018)
RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions
Katrina N. Estep et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2018)
Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies
Anna Minchom et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2018)
Targeting DNA Repair in Cancer : Beyond PARP Inhibitors
Jessica S. Brown et al.
CANCER DISCOVERY (2017)
Coordination of DNA single strand break repair
Rachel Abbotts et al.
FREE RADICAL BIOLOGY AND MEDICINE (2017)
Telomere-driven diseases and telomere-targeting therapies
Paula Martinez et al.
JOURNAL OF CELL BIOLOGY (2017)
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Andrew N. Blackford et al.
MOLECULAR CELL (2017)
BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing
Weixing Zhao et al.
NATURE (2017)
DNA sequencing at 40: past, present and future
Jay Shendure et al.
NATURE (2017)
The control of DNA repair by the cell cycle
Nicole Hustedt et al.
NATURE CELL BIOLOGY (2017)
Synthetic lethality and cancer
Nigel J. O'Neil et al.
NATURE REVIEWS GENETICS (2017)
The impact of replication stress on replication dynamics and DNA damage in vertebrate cells
Herve Techer et al.
NATURE REVIEWS GENETICS (2017)
Mechanisms of DNA-protein crosslink repair
Julian Stingele et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
Robert Hansel-Hertsch et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
DNA-RNA hybrids: the risks of DNA breakage during transcription
Andres Aguilera et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
PARP inhibitors: Synthetic lethality in the clinic
Christopher J. Lord et al.
SCIENCE (2017)
G-Quadruplexes: Prediction, Characterization, and Biological Application
Chun Kit Kwok et al.
TRENDS IN BIOTECHNOLOGY (2017)
PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
Tovah A. Day et al.
NATURE COMMUNICATIONS (2017)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Hong Xu et al.
NATURE COMMUNICATIONS (2017)
DNA-RNA hybrids: the risks of DNA breakage during transcription
Andres Aguilera et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining
Davide Normanno et al.
ELIFE (2017)
Quadruplex nucleic acids as targets for anticancer therapeutics
Stephen Neidle
NATURE REVIEWS CHEMISTRY (2017)
Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole
Takahiro Nakamura et al.
SCIENTIFIC REPORTS (2017)
A phase Ia/Ib trial of the DNA-dependent protein kinase inhibitor (DNA-PKi) M3814 in combination with radiotherapy in patients with advanced solid tumors.
Baukelien Van Triest et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons
Jose F. Moruno-Manchon et al.
AGING-US (2017)
G-quadruplex unwinding helicases and their function in vivo
Markus Sauer et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2017)
Putting p53 in Context
Edward R. Kastenhuber et al.
CELL (2017)
EMICORON: A multi-targeting G4 ligand with a promising preclinical profile
Manuela Porru et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)
Eukaryotic DNA Replication Fork
Peter M. J. Burgers et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 86 (2017)
Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression
Kenneth M. Felsenstein et al.
ACS CHEMICAL BIOLOGY (2016)
Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)
Aziz Sancar
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
The Intrinsic Fragility of DNA (Nobel Lecture)
Tomas Lindahl
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture)
Paul Modrich
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Palindrome analyser - A new web-based server for predicting and evaluating inverted repeats in nucleotide sequences
Vaclav Brazda et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Comparative study of affinity and selectivity of ligands targeting abasic and mismatch sites in DNA using a fluorescence-melting assay
Naoko Kotera et al.
BIOCHIMIE (2016)
Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases
Kimberly J. Zanotti et al.
DNA REPAIR (2016)
Quadruplex Nucleic Acids as Novel Therapeutic Targets
Stephen Neidle
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
Jutta Zimmer et al.
MOLECULAR CELL (2016)
The structural basis of modified nucleosome recognition by 53BP1
Marcus D. Wilson et al.
NATURE (2016)
G-quadruplex structures mark human regulatory chromatin
Robert Hansel-Hertsch et al.
NATURE GENETICS (2016)
G-quadruplexes and helicases
Oscar Mendoza et al.
NUCLEIC ACIDS RESEARCH (2016)
Re-evaluation of G-quadruplex propensity with G4Hunter
Amina Bedrat et al.
NUCLEIC ACIDS RESEARCH (2016)
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
Bryan A. Gibson et al.
SCIENCE (2016)
Targeting WEE1 Kinase in Cancer
Christopher J. Matheson et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
Pauline Chanut et al.
NATURE COMMUNICATIONS (2016)
p53 in the DNA-Damage-Repair Process
Ashley B. Williams et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase
Jun Xia et al.
SCIENCE ADVANCES (2016)
Efficient inhibition of human AP endonuclease 1 (APE1) via substrate masking by abasic site-binding macrocyclic ligands
Naoko Kotera et al.
CHEMICAL COMMUNICATIONS (2015)
New insights into the mechanism of DNA mismatch repair
Gloria X. Reyes et al.
CHROMOSOMA (2015)
The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells
F. Berardinelli et al.
DNA REPAIR (2015)
A history of the DNA repair and mutagenesis field I. The discovery of enzymatic photoreactivation
Errol C. Friedberg
DNA REPAIR (2015)
Historical perspective on the DNA damage response
Philip C. Hanawalt
DNA REPAIR (2015)
Preventing replication fork collapse to maintain genome integrity
David Cortez
DNA REPAIR (2015)
Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites
Aurele Piazza et al.
EMBO JOURNAL (2015)
G4-associated human diseases
Nancy Maizels
EMBO REPORTS (2015)
DNA damage checkpoint recovery and cancer development
Haiyong Wang et al.
EXPERIMENTAL CELL RESEARCH (2015)
The chromatin environment shapes DNA replication origin organization and defines origin classes
Christelle Cayrou et al.
GENOME RESEARCH (2015)
BLM helicase facilitates telomere replication during leading strand synthesis of telomeres
William C. Drosopoulos et al.
JOURNAL OF CELL BIOLOGY (2015)
Drugging Chromatin in Cancer: Recent Advances and Novel Approaches
Sheng F. Cai et al.
MOLECULAR CELL (2015)
Targeting the DNA Damage Response in Cancer
Mark J. O'Connor
MOLECULAR CELL (2015)
High-throughput sequencing of DNA G-quadruplex structures in the human genome
Vicki S. Chambers et al.
NATURE BIOTECHNOLOGY (2015)
Exploiting replicative stress to treat cancer
Matthias Dobbelstein et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase
Michael C. Chen et al.
NUCLEIC ACIDS RESEARCH (2015)
G-quadruplexes and their regulatory roles in biology
Daniela Rhodes et al.
NUCLEIC ACIDS RESEARCH (2015)
Cationic azacryptands as selective three-way DNA junction binding agents
Jana Novotna et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
Triptycene-based small molecules modulate (CAG).(CTG) repeat junctions
Stephanie A. Barros et al.
CHEMICAL SCIENCE (2015)
Mechanisms of Gene Duplication and Amplification
Andrew B. Reams et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis
Sandeep S. Negi et al.
ONCOTARGET (2015)
Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes
Steve Lu et al.
CELL REPORTS (2015)
Mechanism and Regulation of Meiotic Recombination Initiation
Isabel Lam et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
Therapeutic opportunities within the DNA damage response
Laurence H. Pearl et al.
NATURE REVIEWS CANCER (2015)
Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3
Wan Jun Chung et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Small-molecule quadruplex-targeted drug discovery
Stephan A. Ohnmacht et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Programmed stereoselective assembly of DNA-binding helical metallopeptides
Ilaria Gamba et al.
CHEMICAL COMMUNICATIONS (2014)
Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules
Anton Granzhan et al.
CHEMICAL SOCIETY REVIEWS (2014)
The complex choreography of transcription-coupled repair
Graciela Spivak et al.
DNA REPAIR (2014)
Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability
Guliang Wang et al.
DNA REPAIR (2014)
Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3
Carole Beck et al.
EXPERIMENTAL CELL RESEARCH (2014)
Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
Angela Rizzo et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)
IgH Chain Class Switch Recombination: Mechanism and Regulation
Janet Stavnezer et al.
JOURNAL OF IMMUNOLOGY (2014)
Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand
Marco Di Antonio et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD
Lucas T. Gray et al.
NATURE CHEMICAL BIOLOGY (2014)
Mechanisms underlying mutational signatures in human cancers
Thomas Helleday et al.
NATURE REVIEWS GENETICS (2014)
Unravelling the genomic targets of small molecules using high-throughput sequencing
Raphael Rodriguez et al.
NATURE REVIEWS GENETICS (2014)
Double-strand break repair: 53BP1 comes into focus
Stephanie Panier et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Detection of G-quadruplex DNA in mammalian cells
Alexander Henderson et al.
NUCLEIC ACIDS RESEARCH (2014)
PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways
Carole Beck et al.
NUCLEIC ACIDS RESEARCH (2014)
DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal
Sebastien Britton et al.
NUCLEIC ACIDS RESEARCH (2014)
G-quadruplex interacting small molecules and drugs: from bench toward bedside
Sebastian Mueller et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2014)
Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage
Ludovic Deriano et al.
ANNUAL REVIEW OF GENETICS, VOL 47 (2013)
Causes of Genome Instability
Andres Aguilera et al.
ANNUAL REVIEW OF GENETICS, VOL 47 (2013)
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
Luis Ignacio Toledo et al.
CELL (2013)
DNA Sequences That Interfere with Transcription: Implications for Genome Function and Stability
Boris P. Belotserkovskii et al.
CHEMICAL REVIEWS (2013)
Structure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapies
Thomas P. Matthews et al.
EXPERT OPINION ON DRUG DISCOVERY (2013)
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability
Sanjay Kumar Bharti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
FANCJ couples replication past natural fork barriers with maintenance of chromatin structure
Rebekka A. Schwab et al.
JOURNAL OF CELL BIOLOGY (2013)
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
Sebastien Britton et al.
JOURNAL OF CELL BIOLOGY (2013)
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span
L. Ashley Watson et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site
Chuanqi Zhao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
Keith I. E. McLuckie et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Solution Structure of an Intramolecular (3+1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative
Wan Jun Chung et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Double strand break repair functions of histone H2AX
Ralph Scully et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2013)
Pif1 family helicases suppress genome instability at G-quadruplex motifs
Katrin Paeschke et al.
NATURE (2013)
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
Molly C. Kottemann et al.
NATURE (2013)
The causes and consequences of genetic heterogeneity in cancer evolution
Rebecca A. Burrell et al.
NATURE (2013)
Quantitative visualization of DNA G-quadruplex structures in human cells
Giulia Biffi et al.
NATURE CHEMISTRY (2013)
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Yosef Shiloh et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Tumor Cell Death Mediated by Peptides That Recognize Branched Intermediates of DNA Replication and Repair
Mamon Dey et al.
PLOS ONE (2013)
RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication
Jean-Baptiste Vannier et al.
SCIENCE (2013)
Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?
Viktor Brabec et al.
CHEMICAL SCIENCE (2013)
DNA helicases involved in DNA repair and their roles in cancer
Robert M. Brosh
NATURE REVIEWS CANCER (2013)
A Note From History: Landmarks in History of Cancer, Part 4
Steven I. Hajdu
CANCER (2012)
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
Junko Murai et al.
CANCER RESEARCH (2012)
RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity
Jean-Baptiste Vannier et al.
CELL (2012)
Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death
Laurent R. Gauthier et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
Assessing the Differential Affinity of Small Molecules for Noncanonical DNA Structures
Loic Stefan et al.
CHEMBIOCHEM (2012)
Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry
Lesley A. Howell et al.
CHEMMEDCHEM (2012)
Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb
Takeshi Miyazaki et al.
CLINICAL CANCER RESEARCH (2012)
Chromosomal translocations and palindromic AT-rich repeats
Takema Kato et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2012)
Experimental Methods for Studying the Interactions between G-Quadruplex Structures and Ligands
Joaquim Jaumot et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Phase II Activity of Belinostat (PXD-101), Carboplatin, and Paclitaxel in Women With Previously Treated Ovarian Cancer
Don S. Dizon et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2012)
Biochemical Characterization of Warsaw Breakage Syndrome Helicase
Yuliang Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Replication-Independent Repair of DNA Interstrand Cross links
Hannah L. Williams et al.
MOLECULAR CELL (2012)
Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase
Ketki Karanam et al.
MOLECULAR CELL (2012)
R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
Paul A. Ginno et al.
MOLECULAR CELL (2012)
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
Raphael Rodriguez et al.
NATURE CHEMICAL BIOLOGY (2012)
Repetitive DNA and next-generation sequencing: computational challenges and solutions
Todd J. Treangen et al.
NATURE REVIEWS GENETICS (2012)
DNA secondary structures: stability and function of G-quadruplex structures
Matthew L. Bochman et al.
NATURE REVIEWS GENETICS (2012)
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics
Mustapha Haddach et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks
Pierre Caron et al.
PLOS GENETICS (2012)
Synthetic lethality: exploiting the addiction of cancer to DNA repair
Montaser Shaheen et al.
BLOOD (2011)
A Note From History: Landmarks in History of Cancer, Part 1
Steven I. Haidu
CANCER (2011)
Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Denis Drygin et al.
CANCER RESEARCH (2011)
DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase
Katrin Paeschke et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Methods for investigating G-quadruplex DNA/ligand interactions
Pierre Murat et al.
CHEMICAL SOCIETY REVIEWS (2011)
Conformational changes of non-B DNA
Jungkweon Choi et al.
CHEMICAL SOCIETY REVIEWS (2011)
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Yan Xu
CHEMICAL SOCIETY REVIEWS (2011)
Chiral Metallo-Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions
Chuanqi Zhao et al.
CHEMISTRY-A EUROPEAN JOURNAL (2011)
DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents
Annamaria Biroccio et al.
CLINICAL CANCER RESEARCH (2011)
G-quadruplex-induced instability during leading-strand replication
Judith Lopes et al.
EMBO JOURNAL (2011)
PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining
Stuart L. Rulten et al.
MOLECULAR CELL (2011)
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands
Deepak Koirala et al.
NATURE CHEMISTRY (2011)
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Shankar Balasubramanian et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
Jasmine S. Smith et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
Monika Aggarwal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Telomerase Discovery: The Excitement of Putting Together Pieces of the Puzzle (Nobel Lecture)
Carol W. Greider
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
DNA Ends: Just the Beginning (Nobel Lecture)
Jack W. Szostak
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Noncovalent DNA-Binding Metallo-Supramolecular Cylinders Prevent DNA Transactions in vitro
Cosimo Ducani et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Telomeres and Telomerase: The Means to the End (Nobel Lecture)
Elizabeth H. Blackburn
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Non-B DNA structure-induced genetic instability and evolution
Junhua Zhao et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2010)
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians
Rachel Litman Flynn et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)
The distribution of inverted repeat sequences in the Saccharomyces cerevisiae genome
Eva M. Strawbridge et al.
CURRENT GENETICS (2010)
Detecting hydrophobic molecules with nucleic acid-based receptors
Milan N. Stojanovic et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
SF1 and SF2 helicases: family matters
Margaret E. Fairman-Williams et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)
A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin
Flurina J. Hari et al.
EMBO REPORTS (2010)
Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex
Michal Hammel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The DNA Damage Response: Making It Safe to Play with Knives
Alberto Ciccia et al.
MOLECULAR CELL (2010)
Small-molecule-mediated G-quadruplex isolation from human cells
Sebastian Mueller et al.
NATURE CHEMISTRY (2010)
Mechanisms of trinucleotide repeat instability during human development
Cynthia T. McMurray
NATURE REVIEWS GENETICS (2010)
Genomic instability - an evolving hallmark of cancer
Simona Negrini et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Mre11-Rad50-Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks
Matthew L. Nicolette et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
ATR contributes to telomere maintenance in human cells
Gaelle Pennarun et al.
NUCLEIC ACIDS RESEARCH (2010)
Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae
Aurele Piazza et al.
NUCLEIC ACIDS RESEARCH (2010)
PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy
E. Salvati et al.
ONCOGENE (2010)
How the Fanconi Anemia Pathway Guards the Genome
George-Lucian Moldovan et al.
ANNUAL REVIEW OF GENETICS (2009)
Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
Denis Drygin et al.
CANCER RESEARCH (2009)
The State of the Art of Chemical Biology
Karl-Heinz Altmann et al.
CHEMBIOCHEM (2009)
A study on genomic distribution and sequence features of human long inverted repeats reveals species-specific intronic inverted repeats
Yong Wang et al.
FEBS JOURNAL (2009)
G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells
Wen-Jun Zhou et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
Sandie Tuduri et al.
NATURE CELL BIOLOGY (2009)
Src kinases as therapeutic targets for cancer
Lori C. Kim et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2009)
Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility
Irina Voineagu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
Angela Rizzo et al.
NUCLEIC ACIDS RESEARCH (2009)
The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells
Nassima Temime-Smaali et al.
PLOS ONE (2009)
The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo
Cyril Ribeyre et al.
PLOS GENETICS (2009)
RecQ helicases: multifunctional genome caretakers
Wai Kit Chu et al.
NATURE REVIEWS CANCER (2009)
Cell cycle, CDKs and cancer: a changing paradigm
Marcos Malumbres et al.
NATURE REVIEWS CANCER (2009)
Targeting DNA topoisomerase II in cancer chemotherapy
John L. Nitiss
NATURE REVIEWS CANCER (2009)
Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex binders
Masayuki Tera et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Targeting telomeres and telomerase
Anne De Cian et al.
BIOCHIMIE (2008)
Supramolecular Iron Cylinder with Unprecedented DNA Binding Is a Potent Cytostatic and Apoptotic Agent without Exhibiting Genotoxicity
Anna C. G. Hotze et al.
CHEMISTRY & BIOLOGY (2008)
G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors
Carlo Leonetti et al.
CLINICAL CANCER RESEARCH (2008)
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
J. Ross Chapman et al.
EMBO REPORTS (2008)
p21 and p27: roles in carcinogenesis and drug resistance
Abde M. Abukhdeir et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2008)
FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
Timothy B. C. London et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates
Steven D. Creacy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
DNA damage and repair: Relevance to mechanisms of neurodegeneration
Lee J. Martin
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
Raphael Rodriguez et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Single-strand break repair and genetic disease
Keith W. Caldecott
NATURE REVIEWS GENETICS (2008)
ATR: an essential regulator of genome integrity
Karlene A. Cimprich et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Role of ATM in the telomere response to the G-quadruplex ligand 360A
Gaelle Pennarun et al.
NUCLEIC ACIDS RESEARCH (2008)
Interactions between branched DNAs and peptide inhibitors of DNA repair
Kevin V. Kepple et al.
NUCLEIC ACIDS RESEARCH (2008)
The triple helix: 50 years later, the outcome
Maria Duca et al.
NUCLEIC ACIDS RESEARCH (2008)
A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity
SunMi L. Palumbo et al.
NUCLEIC ACIDS RESEARCH (2008)
Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA
Haijia Yu et al.
NUCLEIC ACIDS RESEARCH (2008)
A hitchhiker's guide to G-quadruplex ligands
David Monchaud et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2008)
Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins
Irina Voineagu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
Mitch McVey et al.
TRENDS IN GENETICS (2008)
Telomere dysfunction and tumour suppression: the senescence connection
Yibin Deng et al.
NATURE REVIEWS CANCER (2008)
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
Erica Salvati et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action
Anne De Cian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Nucleotide excision repair and homologous recombination systems commit differentially to the repair of DNA-Protein crosslinks
Toshiaki Nakano et al.
MOLECULAR CELL (2007)
Nucleotide excision repair eliminates unique DNA-protein cross-links from mammalian cells
David J. Baker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Treatment for chronic myelogenous leukemia: the long road to imatinib
Tony Hunter
JOURNAL OF CLINICAL INVESTIGATION (2007)
RPA and ATR link transcriptional stress to p53
Frederick A. Derheimer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Direct cellular responses to platinum-induced DNA damage
Yongwon Jung et al.
CHEMICAL REVIEWS (2007)
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
P. Phatak et al.
BRITISH JOURNAL OF CANCER (2007)
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
Benjamin P. C. Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin
Katerina Chvalova et al.
NUCLEIC ACIDS RESEARCH (2007)
Highly efficient G-quadruplex recognition by bisquinolinium compounds
Anne De Cian et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Dinuclear ruthenium(II) triple-stranded helicates: Luminescent supramolecular cylinders that bind and coil DNA and exhibit activity against cancer cell lines
Gabriel I. Pascu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Repair of alkylated DNA: Recent advances
Barbara Sedgwick et al.
DNA REPAIR (2007)
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells
Dennis Gomez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Characterization of structure and stability of long telomeric DNA G-quadruplexes
Hai-Qing Yu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Quadruplex DNA: sequence, topology and structure
Sarah Burge et al.
NUCLEIC ACIDS RESEARCH (2006)
Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events
Harald Loeffler et al.
CELL CYCLE (2006)
Topoisomerase I inhibitors: camptothecins and beyond
Yves Pommier
NATURE REVIEWS CANCER (2006)
Structure of the human telomere in K+ solution:: An intramolecular (3+1) G-quadruplex scaffold
Kim Ngoc Luu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Gene amplification in cancer
Donna G. Albertson
TRENDS IN GENETICS (2006)
Novel antibiotics:: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E-coli RuvC
Po-Shen Pan et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
The multifaceted mismatch-repair system
J Jiricny
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks
Kristina Trenz et al.
EMBO JOURNAL (2006)
DNA repair, a novel antibacterial target: Holliday junction-trapping peptides induce DNA damage and chromosome segregation defects
CW Gunderson et al.
MOLECULAR MICROBIOLOGY (2006)
Molecular recognition of a three-way DNA junction by a metallosupramolecular helicate
A Oleksi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A Jazayeri et al.
NATURE CELL BIOLOGY (2006)
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
M Stucki et al.
CELL (2005)
The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates
JP Vaughn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the γ-H2AX histone tail
MS Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Shelterin: the protein complex that shapes and safeguards human telomeres
T de Lange
GENES & DEVELOPMENT (2005)
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
AT Phan et al.
NATURE CHEMICAL BIOLOGY (2005)
Holliday junction-binding peptides inhibit distinct junction-processing enzymes
KV Kepple et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Ionizing radiation-dependent γ-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related
JD Friesner et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
BL Staker et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives
J Tazi et al.
MOLECULAR PHARMACOLOGY (2005)
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
J Falck et al.
NATURE (2005)
Peptide trapping of the Holliday junction intermediate in Cre-loxP site-specific recombination
K Ghosh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Friedrich Miescher and the discovery of DNA
R Dahm
DEVELOPMENTAL BIOLOGY (2005)
The concept of synthetic lethality in the context of anticancer therapy
WG Kaelin
NATURE REVIEWS CANCER (2005)
Highly prevalent putative quadruplex sequence motifs in human DNA
AK Todd et al.
NUCLEIC ACIDS RESEARCH (2005)
Preferential binding of a G-quadruplex ligand to human chromosome ends
C Granotier et al.
NUCLEIC ACIDS RESEARCH (2005)
Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration
C Leonetti et al.
MOLECULAR PHARMACOLOGY (2004)
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding
MS Chen et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways
T Tauchi et al.
ONCOGENE (2003)
Regulating mammalian checkpoints through Cdc25 inactivation
M Donzelli et al.
EMBO REPORTS (2003)
Cross-reactive arrays based on three-way junctions
MN Stojanovic et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
5-Fluorouracil: Mechanisms of action and clinical strategies
DB Longley et al.
NATURE REVIEWS CANCER (2003)
ATM and related protein kinases: Safeguarding genome integrity
Y Shiloh
NATURE REVIEWS CANCER (2003)
MDC1 is required for the intra-S-phase DNA damage checkpoint
M Goldberg et al.
NATURE (2003)
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
ZK Lou et al.
NATURE (2003)
MDC1 is a mediator of the mammalian DNA damage checkpoint
GS Stewart et al.
NATURE (2003)
Novel antibiotics: Macrocyclic peptides designed to trap Holliday junctions
ML Bolla et al.
ORGANIC LETTERS (2003)
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
V Costanzo et al.
MOLECULAR CELL (2003)
Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA
I Cheung et al.
NATURE GENETICS (2002)
Crystal structure of parallel quadruplexes from human telomeric DNA
GN Parkinson et al.
NATURE (2002)
DNA and its associated processes as targets for cancer therapy
LH Hurley
NATURE REVIEWS CANCER (2002)
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
JL Li et al.
BIOCHEMISTRY (2001)
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
S Burma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
P Mohaghegh et al.
NUCLEIC ACIDS RESEARCH (2001)
Aptamer-based folding fluorescent sensor for cocaine
MN Stojanovic et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Substrate-specific inhibition of RecQ helicase
X Wu et al.
NUCLEIC ACIDS RESEARCH (2001)
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus
K Shin-ya et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases
AR Lehmann
GENES & DEVELOPMENT (2001)
Fluorescent sensors based on aptamer self-assembly
MN Stojanovic et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N′-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand
HY Han et al.
BIOCHEMISTRY (2000)
Enzymatic photoreactivation: 50 years and counting
GB Sancar
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2000)
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
A de Klein et al.
CURRENT BIOLOGY (2000)
Structures of helical junctions in nucleic acids
DMJ Lilley
QUARTERLY REVIEWS OF BIOPHYSICS (2000)
Repair of endogenous DNA damage
T Lindahl et al.
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (2000)
Share Paper
