Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. alpha-Helix mimetics-small molecules that reproduce the spatial projection of key residues from an alpha-helix involved in a PPI-are attractive generic templates for development of screening libraries, however library syntheses of alpha-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-allcylated oligobenzamide. (C) 2012 Elsevier Ltd. All rights reserved.