Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 20, Issue 8, Pages 2558-2563Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.02.049
Keywords
Anticancer; Naphthalimides; Selenium; K562; DNA
Funding
- National Basic Research Program of China (973 Program) [2010CB126100]
- National High Technology Research, the Development Program of China (863 Program) [2011AA10A207]
- National Key Technology R&D Program of China [2011BAE06B01]
- Fundamental Research Funds for the Central Universities
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Selenium analogues (4b-4h, and 4j) of two known sulfur compounds were synthesized and tested their anticancer activities. The selenium compound 4b had comparable activity with its sulfur analogue 4a, while DNA-binding study showed these two compounds had similar interaction with ct-DNA, the K-b was 8.23 and 2.36, respectively. The primary results showed that most compounds had moderate anticancer activities with IC50 values between 10 (6) and 10 (5) M. Another selenium analogue 4j showed the highest activity with the IC50 values around 5.3 mu M against K562 and MCF-7 cell lines. More importantly, the organochalcogen compounds exhibited stronger anticancer activities against K562 cell line than the other cell lines tested. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
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