Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 20, Issue 15, Pages 4668-4674Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.06.013
Keywords
HNO; F-19 NMR probe; POSS; Paramagnetic relaxation enhancement
Funding
- Shimadzu Science Foundation
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The F-19 NMR probes for the HNO detection are reported. We synthesized the probe molecules with the paramagnetic Cu(II) complex and fluorine atoms using a cubic silsesquioxane. By using the magnetism changes of the Cu(II) to Cu(I) in the complex by the reduction with HNO, the F-19 NMR signal intensities of the probe increased. Noteworthily, our probes have superior resistance to reduced glutathione which is the major intracellular molecule to maintain the reductive environment and the competitor in the reduction of Cu(II) against HNO. (C) 2012 Elsevier Ltd. All rights reserved.
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