Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 20, Issue 13, Pages 4082-4087Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.05.002
Keywords
beta-Carboline alkaloids; Eudistomin Y class; Synoicum sp.; Chemical modification; Bioactivity
Funding
- Ministry of education, Korea
- National Research Foundation of Korea (NRF)
- Korean government (MEST, Ministry of Education, Science and Technology [20110030638, 20110018562]
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Six beta-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y-1 (7) and six new derivatives, designated eudistomins Y-8-Y-13 (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na+/K+-ATPase. Structure-activity relationships were also deduced. (C) 2012 Elsevier Ltd. All rights reserved.
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