Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 20, Issue 8, Pages 2675-2678Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.02.028
Keywords
Gasotransmitters; Hydrogen sulfidel; Thiovalin; Thioglycin
Funding
- European Union
- Greek national funds through the operational Program 'Education and Lifelong Learning' of the National Strategic Reference Framework (NSRF) - Research Funding Program: Thalis, Investing in knowledge society through the European Social Fund
- Shriners' Burns Hospitals [8661]
- COST Action [BM1005]
- University of Leipzig
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Thioglycine and L-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H2S donors hold promise as novel treatments for cardiovascular diseases. (C) 2012 Elsevier Ltd. All rights reserved.
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