4.3 Article

Utilization of ethanol for itaconic acid biosynthesis by engineered Saccharomyces cerevisiae

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Engineering Yarrowia lipolytica for the selective and high-level production of isocitric acid through manipulation of mitochondrial dicarboxylate?tricarboxylate carriers

Evgeniya Y. Yuzbasheva et al.

Summary: The mitochondrial succinate-fumarate carrier YlSfc1 controls the efflux of isocitric acid from mitochondria in Yarrowia lipolytica, with its overexpression leading to increased production of isocitric acid. Coordinating the expression of YlSFC1 and YlAMPD genes, along with inactivating the YlYHM2 gene, enhances the accumulation of isocitric acid. This study demonstrates the potential of manipulating mitochondrial transport systems to improve product accumulation.

METABOLIC ENGINEERING (2021)

Article Biotechnology & Applied Microbiology

Constructing an ethanol utilization pathway in Escherichia coli to produce acetyl-CoA derived compounds

Hong Liang et al.

Summary: By engineering microbes, a two-step heterologous ethanol utilization pathway was designed and constructed in Escherichia coli to convert ethanol into acetyl-CoA efficiently without ATP consumption. The optimized pathway generated two molecules of NADH per molecule of ethanol. The engineered E. coli strain successfully consumed approximately 8 g/L of ethanol as the sole carbon source, and produced 1.1 g/L of polyhydroxybutyrate in combination with the biosynthetic pathway within 96 h. Moreover, the feasibility of converting ethanol into different classes of acetyl-CoA derived compounds was demonstrated by producing prenol in an engineered E. coli strain.

METABOLIC ENGINEERING (2021)

Article Agriculture, Multidisciplinary

Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene

Tian Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Review Biochemical Research Methods

Metabolic specialization in itaconic acid production: a tale of two fungi

Nick Wierckx et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism

Qin Xu et al.

BIOTECHNOLOGY FOR BIOFUELS (2019)

Article Biotechnology & Applied Microbiology

Engineering the morphology and metabolism of pH tolerant Ustilago cynodontis for efficient itaconic acid production

Hamed Hosseinpour Tehrani et al.

METABOLIC ENGINEERING (2019)

Article Multidisciplinary Sciences

Carbon Catabolite Repression in Yeast is Not Limited to Glucose

Kobi Simpson-Lavy et al.

SCIENTIFIC REPORTS (2019)

Article Biotechnology & Applied Microbiology

Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger

Abeer H. Hossain et al.

BIOTECHNOLOGY FOR BIOFUELS (2019)

Article Biotechnology & Applied Microbiology

Integrated strain- and process design enable production of 220 g L-1 itaconic acid with Ustilago maydis

Hamed Hosseinpour Tehrani et al.

BIOTECHNOLOGY FOR BIOFUELS (2019)

Article Biotechnology & Applied Microbiology

Process engineering of pH tolerant Ustilago cynodontis for efficient itaconic acid production

Hamed Hosseinpour Tehrani et al.

MICROBIAL CELL FACTORIES (2019)

Article Biotechnology & Applied Microbiology

Central pathway engineering for enhanced succinate biosynthesis from acetate in Escherichia coli

Bing Huang et al.

BIOTECHNOLOGY AND BIOENGINEERING (2018)

Article Biotechnology & Applied Microbiology

Iterative algorithm-guided design of massive strain libraries, applied to itaconic acid production in yeast

Eric M. Young et al.

METABOLIC ENGINEERING (2018)

Article Biotechnology & Applied Microbiology

Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli

Bjoern-Johannes Harder et al.

BIOTECHNOLOGY AND BIOENGINEERING (2018)

Article Biotechnology & Applied Microbiology

Production of itaconic acid from acetate by engineering acid-tolerant Escherichia coli W

Myung Hyun Noh et al.

BIOTECHNOLOGY AND BIOENGINEERING (2018)

Article Biochemical Research Methods

Bio-Based Production of Dimethyl Itaconate From Rice Wine Waste-Derived Itaconic Acid

Young-Chul Joo et al.

BIOTECHNOLOGY JOURNAL (2017)

Article Biotechnology & Applied Microbiology

Process development of itaconic acid production by a natural wild type strain of Aspergillus terreus to reach industrially relevant final titers

Susan Krull et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2017)

Review Chemistry, Multidisciplinary

Itaconic acid - a versatile building block for renewable polyesters with enhanced functionality

Tobias Robert et al.

GREEN CHEMISTRY (2016)

Article Multidisciplinary Sciences

Rewriting yeast central carbon metabolism for industrial isoprenoid production

Adam L. Meadows et al.

NATURE (2016)

Review Nutrition & Dietetics

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

Thekla Cordes et al.

ANNUAL REVIEW OF NUTRITION, VOL 35 (2015)

Article Biotechnology & Applied Microbiology

Metabolic engineering of Corynebacterium glutamicum for the production of itaconate

Andreas Otten et al.

METABOLIC ENGINEERING (2015)

Article Biotechnology & Applied Microbiology

Metabolic engineering of Yarrowia lipolytica for itaconic acid production

John Blazeck et al.

METABOLIC ENGINEERING (2015)

Article Biochemistry & Molecular Biology

The Ubiquitin Ligase SCFUcc1 Acts as a Metabolic Switch for the Glyoxylate Cycle

Kunio Nakatsukasa et al.

MOLECULAR CELL (2015)

Article Biotechnology & Applied Microbiology

Metabolic pathway engineering for fatty acid ethyl ester production in Saccharomyces cerevisiae using stable chromosomal integration

Bouke Wim de Jong et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2015)

Article Biotechnology & Applied Microbiology

Construction of a Quadruple Auxotrophic Mutant of an Industrial Polyploid Saccharomyces cerevisiae Strain by Using RNA-Guided Cas9 Nuclease

Guo-Chang Zhang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production

John Blazeck et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Replacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis

Barbara U. Kozak et al.

METABOLIC ENGINEERING (2014)

Article Biochemistry & Molecular Biology

Regulation of yeast central metabolism by enzyme phosphorylation

Ana Paula Oliveira et al.

MOLECULAR SYSTEMS BIOLOGY (2012)

Article Endocrinology & Metabolism

Non-targeted metabolite profiling in activated macrophage secretion

Masahiro Sugimoto et al.

METABOLOMICS (2012)

Article Biotechnology & Applied Microbiology

Biochemical characterisation of aconitase from Corynebacterium glutamicum

Meike Baumgart et al.

JOURNAL OF BIOTECHNOLOGY (2011)

Article Biochemistry & Molecular Biology

TCA cycle-independent acetate metabolism via the glyoxylate cycle in Saccharomyces cerevisiae

Yong Joo Lee et al.

YEAST (2011)