Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 3, Pages 1136-1154Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.12.038
Keywords
Synthesis; New drug molecules; New chemical entities; Medicine; Therapeutic agents
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New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the syntheses of 21 NCEs marketed in 2009. (C) 2011 Elsevier Ltd. All rights reserved.
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