Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase

Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities with IC50 values ranged between 4.31 +/- 0.001 and 29.12 +/- 0.008 mu mol. Compounds derived from 6-fluoro-3-formylchromones were the most active. (C) 2011 Elsevier Ltd. All rights reserved.