Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 23, Pages 7221-7227Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.09.043
Keywords
Dipeptidyl peptidase IV; DPP-IV inhibitor; Pyrazolo[1,5-a]pyrimidine; Anagliptin; Glucagon-like peptide-1; Type 2 diabetes mellitus
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In the course of our program for discovery of novel DPP-IV inhibitors, a series of pyrazolo[1,5-a]pyrimidines were found to be novel DPP-IV inhibitors. We identified N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (4a) and described its pharmacological profiles. (C) 2011 Elsevier Ltd. All rights reserved.
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