Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 22, Pages 6594-6598Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.06.052
Keywords
Sponge; Structure elucidation; Steroid; Dimeric; Crellastatin; Cathepsin B
Funding
- MEXT [16073207]
- Grants-in-Aid for Scientific Research [16073207] Funding Source: KAKEN
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Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC(50) value of 8 mu g/mL each. (C) 2011 Elsevier Ltd. All rights reserved.
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