Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 7, Pages 2282-2286Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.02.027
Keywords
Arsonic acid; Superparamagnetic iron oxide; pH-responsiveness; Nanoparticle
Funding
- Grants-in-Aid for Scientific Research [22750107, 22655033] Funding Source: KAKEN
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We report the synthesis and characterization of the arsonic acid-presenting superparamagnetic iron oxide (SPIO). We used arsonoacetic acid as the ligand for SPIOs in aqueous media. The surface modification of the SPIOs was accomplished via the ligand exchange from undecanoic acid to the carboxyl moiety of arsonoacetic acid. Consequently, the well-dispersed arsonic acid-presenting SPIOs in water were obtained. We found that the dispersion state of the arsonic acid-presenting SPIOs can be sharply regulated by pH changes in the biological significant region. The well dispersion state of the arsonic acid-presenting SPIOs can be maintained at the neutral pH region. In contrast, the arsonic acid-presenting SPIOs can sensitively form the aggregation below pH 6.1. Moreover, these dispersion states can be controlled reversibly by the pH alteration in the narrow region. (C) 2011 Elsevier Ltd. All rights reserved.
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