Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 7, Pages 2418-2427Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.02.010
Keywords
Sialic acid; 2-Deoxy-2,3-didehydro-N-acetylneuraminic acid; Three-component coupling reaction; N-Sulfonylamidino group; Human parainfluenza virus type 1 sialidase inhibition
Funding
- Ministry of Education, Science, Sports, and Culture of Japan [21590117]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [21590117, 23590549] Funding Source: KAKEN
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Eleven novel sialidase inhibitors 9 and 10 with an N-sulfonylamidino group at the C-4 position of Neu 5Ac2en 1 against human parainfluenza virus type 1 (hPIV-1) were synthesized using copper-catalyzed three-component coupling reactions, and their inhibitory activities against hPIV-1 sialidase were studied. (C) 2011 Elsevier Ltd. All rights reserved.
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