Adenovirus Vectors: Excellent Tools for Vaccine Development

Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to increase. Adenovirus-based vaccines are currently being tested not only to prevent various infectious diseases but also to be applied as cancer vaccines. In this review, I discuss the innate and adaptive aspects of the immunological characteristics of adenovirus vectors and further examine the current status of advanced adenovirus-based vaccine development. Various methods that can overcome the limitations of currently used adenoviruses as vaccine vehicles are also discussed. Through this study, I hope that vaccine development using adenovirus vectors will be expedited and more successful.

Automated summary

Adenovirus, originally used for gene therapy, has seen increased utility as a vaccine vector in recent years with higher safety and immunogenicity. It is being tested for preventing infectious diseases and as cancer vaccines, with ongoing research to overcome limitations for improved vaccine development using adenovirus vectors.