Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 16, Pages 4928-4934Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.06.060
Keywords
Antimigratory; Breast cancer; Carbamoylation; Cembranoids; Etherification; Prostate cancer; Semisynthesis; Wound-healing
Funding
- Louisiana Board of Regents [LEQSF(2010-11)-ENH-TR-41]
- Egyptian government
Ask authors/readers for more resources
Sarcophine (1) is a bioactive cembranoid diterpene isolated from the Red Sea soft coral Sarcophyton glaucum. Previous semisynthesis attempts resulted in decreased or complete loss of 1's anticancer activity. Sarcophine and analogues showed antimigratory activity against breast and prostate cancer cell lines. This encouraged further semisynthestic optimizations to improve its activity and establish a preliminary structure-activity relationship. Eight new and five known semisynthetic analogues were generated. These compounds were evaluated for their ability to inhibit growth, proliferation, and migration of the prostate and breast metastatic cancer cell lines PC-3 and MDA-MB-231, respectively. Most analogues exhibited enhanced antimigratory activity. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available