Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 22, Pages 6702-6719Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.06.083
Keywords
Marine diterpene glycoside; Natural product; Synthesis; Biosynthesis; Coral
Funding
- NSERC
- Canada Research Chair Program
- University of Prince Edward Island, Atlantic Canada Opportunities Agency
- Jeanne and Jean-Louis Levesque Foundation
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Marine diterpene glycosides (MDGs) respresent a small but highly significant group of the much larger class of marine diterpenes. The three well-studied examples of MDGs are eleutherobins, pseudopterosins and fuscosides, all of which exhibit extremely promising biological activity. The eleutherobins are potent anti-mitotic agents, and the pseudopterosins and fuscosides are potent anti-inflammatory agents. This review discusses the structures and biological activities of these compounds, as well as their biosynthesis and synthesis. (C) 2011 Elsevier Ltd. All rights reserved.
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