Journal
AIMS BIOPHYSICS
Volume 8, Issue 1, Pages 111-120Publisher
AMER INST MATHEMATICAL SCIENCES-AIMS
DOI: 10.3934/biophy.2021008
Keywords
coronavirus; COVID-19; SARS-CoV-2; fusion; amino acids; electric field; charge; electrostatic potential; anions; vitamin C
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The charged amino acids in the spike protein of SARS-CoV-2 show specific distribution, which may facilitate virus infection of the cell through electrostatic means.
The charged amino acids in the spike protein of SARS-CoV-2 exhibit some specific distribution. In the RBD region of the S1 unit the positive charge dominates in the protein interior and the negative charge prevails on the surface exposed towards ACE2 receptor. The charged amino acids in the S2 region preceding heptad repeats of the spike protein of SARS-CoV-2, exhibit a central concentration, and the imbalance of a positive charge. The idea that both distributions of charged amino acids may, in an electrostatic manner, facilitate the coronavirus infection of the cell is presented. An evaluation of the virus-receptor binding energy, by docking the peptide resembling the human receptor site to the virus RBD, and the estimation of electromechanical deformation of the cell membrane by S2 during the prefusion process were included. Possible prevention of viral infection is suggested.
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