Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 18, Issue 5, Pages 1875-1881Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.01.043
Keywords
Pyrazolines; MAO inhibitors; Molecular docking
Funding
- AICTE
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3,5-Diaryl pyrazolines analogs were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity. The compounds were found reversible and selective towards MAO-A with selectivity index in the magnitude of 10(3)-10(5). The docking studies were carried out to gain further structural insights of the binding mode and possible interactions with the active site of MAO-A. Interestingly, the theoretical (K-i) values obtained by molecular docking studies were in congruence with their experimental (K-i) values. (C) 2010 Elsevier Ltd. All rights reserved.
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