Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 18, Issue 16, Pages 5816-5825Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.06.090
Keywords
Phenolic antioxidants; Lipid peroxidation; Redox potentials; Partition coefficients
Funding
- FCT (Fundacao para a Ciencia e Tecnologia)
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Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation between the redox potentials and the antioxidant activity. In addition, some compounds showed a proper lipophilicity to cross the blood-brain barrier. Their predicted ADME properties are also in accordance with the general requirements for potential CNS drugs. Accordingly, one can propose these phenolic compounds as potential antioxidants for tackling the oxidative status linked to the neurodegenerative processes. (C) 2010 Elsevier Ltd. All rights reserved.
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