Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 18, Issue 1, Pages 426-432Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.10.041
Keywords
4-Thiazolidinone; Antibacterial; Antifungal; Z/E isomerism
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As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs. (C) 2009 Elsevier Ltd. All rights reserved.
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