Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 117, Issue 2, Pages 289-299Publisher
WILEY
DOI: 10.1002/jcb.25291
Keywords
PAGET'S DISEASE; BONE DISEASE; BISPHOSPHONATES
Categories
Funding
- Arthritis Research UK
- MRC [G0701625] Funding Source: UKRI
- Medical Research Council [G0701625] Funding Source: researchfish
- Versus Arthritis [19799] Funding Source: researchfish
Ask authors/readers for more resources
Paget's disease of bone (PDB) is a common skeletal disorder characterized by increased and disorganized bone remodeling affecting one or more skeletal sites. Although some patients are asymptomatic others develop complications such as bone pain, deformity, nerve compression syndromes, and fragility fractures. Genetic factors play an important role in the pathogenesis of PDB and there is strong evidence that susceptibility is determined by variants within or close to genes that regulate osteoclast function. Environmental factors also play a key role but the nature of the environmental triggers is less clear. Bisphosphonates are a highly effective treatment for the elevations in bone turnover that are characteristic of PDB but it is unclear at present if they alter the natural history of the disease. Here, we review the epidemiology, clinical, cellular, and molecular abnormalities in PDB as well as environmental and genetic triggers, and current available treatment options. (C) 2015 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available