Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 18, Issue 4, Pages 1406-1414Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.01.025
Keywords
Biocatalysis; Green chemistry; p-Hydrobenzoquinones; p-Benzoquinones; Diaminobenzoquinones; Laccase; Denilite (R) II Base; Oxidative enzymes
Funding
- CSIR
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Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalysed by an immobilised commercial laccase, Denilite (R) II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions (at room temperature and at 35 degrees C) in a reaction vessel open to air in the presence of laccase and a co-solvent to afford, exclusively, the diaminated p-benzoquinone. These compounds may have potential antiallergic, antibiotic, anticancer, antifungal, antiviral and/or 5-lipoxygenase inhibiting activity. (C) 2010 Elsevier Ltd. All rights reserved.
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