Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 18, Issue 18, Pages 6742-6747Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.07.053
Keywords
Goniothalamin; Cancer; Mice; Ehrlich solid tumor
Funding
- FAPESP [07/58665-7, 09/51602-5]
- CNPq
- Capes
- National Cancer Institute-Frederick, MA, USA
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/51602-5] Funding Source: FAPESP
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In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself. (c) 2010 Elsevier Ltd. All rights reserved.
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