Microbiota control of maternal behavior regulates early postnatal growth of offspring

Maternal behavior is necessary for optimal development and growth of offspring. The intestinal microbiota has emerged as a critical regulator of growth and development in the early postnatal period life. Here, we describe the identification of an intestinal Escherichia coli strain that is pathogenic to the maternal-offspring system during the early postnatal stage of life and results in growth stunting of the offspring. However, rather than having a direct pathogenic effect on the infant, we found that this particular E. coli strain was pathogenic to the dams by interfering with the maturation of maternal behavior. This resulted in malnourishment of the pups and impaired insulin-like growth factor 1 (IGF-1) signaling, leading to the consequential stunted growth. Our work provides a new understanding of how the microbiota regulates postnatal growth and an additional variable that must be considered when studying the regulation of maternal behavior.

Automated summary

Maternal behavior is crucial for the optimal development and growth of offspring, while the intestinal microbiota plays a key role in regulating growth and development. Certain strains of Escherichia coli were found to be pathogenic to the maternal-offspring system, leading to growth stunting by interfering with maternal behavior rather than directly affecting the infants. This study provides new insights into how microbiota regulates postnatal growth and highlights an additional variable to consider when studying the regulation of maternal behavior.