Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 18, Issue 19, Pages 6970-6976Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.08.024
Keywords
N,O-Nucleosides; 1,3-Dipolar cycloaddition; Cytotoxic activity
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Several N,O-nucleosides have been synthesized in good yields by direct 1,3-dipolar cyclization methodology, in the absence of solvent. A remarkable cis stereoselectivity (de 98%) was observed by tuning the substituents on the nitrone moiety. A good number of these N, O-nucleosides have been evaluated for cytotoxic activity against selected cellular lines. Some of the tested compounds have proven to be potential antiproliferative drugs. (C) 2010 Elsevier Ltd. All rights reserved.
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