4.7 Article

Synthesis of tetraglucosyl- and tetrapolyamine-tetrabenzoporphyrin conjugates for an application in PDT

Journal

BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 22, Pages 7647-7657

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.09.048

Keywords

Tetrabenzoporphyrin; Polyamine; Isomaltulose; D-Glucose; PDT

Funding

  1. Conseil Regional du Limousin

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This paper reports the synthesis and characterization of a new class of tetrabenzoporphyrins bearing glucosyl or polyamine units on meso positions to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested on cell lines HaCaT and MCF-7 and compared to Photofrin II (R). (C) 2009 Elsevier Ltd. All rights reserved.

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