Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 2, Pages 625-633Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.11.062
Keywords
Tetrahydropyridines; Antimalarial activity; L-Proline; Organocatalysis; Schizont maturation; Trifluoroacetic acid
Funding
- ICMR
- DBT New Delhi
- CSIR New Delhi [7466]
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A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of beta-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against Plasmodium falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 mu g/mL. (C) 2008 Elsevier Ltd. All rights reserved.
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