Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 116, Issue 10, Pages 2146-2154Publisher
WILEY
DOI: 10.1002/jcb.25203
Keywords
MYELOID; ZINC; FINGER-1; CANCER; INVASION; SUMO; NUCLEAR BODY
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Funding
- NIH [R0-1CA047407, R01CA119045, R0-1CA094397]
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Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors. J. Cell. Biochem. 116: 2146-2154, 2015. (c) 2015 Wiley Periodicals, Inc.
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