4.7 Article

Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens

Journal

BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 4, Pages 1636-1639

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.12.057

Keywords

Taste; Chemesthesis; Channel; TRP

Funding

  1. University of Milano, MIUR (Italian Ministry for University and Research)
  2. MAE (Italian Ministry for Foreigner Affairs)

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Perilla frutescens is a food plant widely used in Asian cuisine. This plant was investigated for its interesting taste and somatosensory properties. Perillaldehyde and perillaketone are among the components of the aromatic extracts from P. Frutescens. These compounds were shown here to activate the cloned TRPA1 channel when expressed in an heterologous cell system and are therefore suggested to be responsible for the chemesthetic properties of this plant. (C) 2009 Elsevier Ltd. All rights reserved.

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