Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 13, Pages 4693-4707Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.04.055
Keywords
3,5-Disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives; Antimycobacterial activity; Molecular modeling
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3H-1,3,4-Oxadiazol-2-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Oxadiazolone derivatives showed an interesting antimycobacterial activity against the reference strain of Mycobacterium tuberculosis H37Rv. Molecular modeling investigations were performed and showed that the active compounds possess all necessary features to target the protein active site of the mycobacterial cytochrome P450-dependent sterol 14 alpha-demethylase in the sterol biosynthesis pathway as the calculated free energy of binding were in agreement with the corresponding MIC values. (C) 2009 Elsevier Ltd. All rights reserved.
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