Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 16, Pages 5900-5905Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.07.001
Keywords
SIRT1 inhibitor; Enzyme assay; Tumor cell growth inhibition; 2-Anilinobenzamide derivative; Daudi cells; HCT116 cells
Funding
- Japan Society for the Promotion of Science
- Grant-in-Aid for Research in Nagoya City University
- Ichihara International Scholarship Foundation
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A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells. (C) 2009 Elsevier Ltd. All rights reserved.
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