Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 2, Pages 585-591Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.11.083
Keywords
Thiazole Orange; Modification; Fluorescence; Label; Breast cancer cells
Funding
- National Natural Science Foundation of China [20672080]
- Key Project of Science and Technology
- Ministry of Education of China [205013]
- Key Project of Science and Technology Committee of Tianjin [08JCZDJC18200]
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A series of Thiazole Orange (TO) derivatives were synthesized and modified by introducing different substitutional groups on benzothiazole and 4-methylquinoline All the TO derivatives were confirmed by (HNMR)-H-1 and MS. TO derivative bearing NH2- was modified by folic acid and used to label breast cancer cells. The phenomenon of fluorescence enhancement was shown by the fluorescence spectrums of TO derivatives and micrographs of the labeled breast cancer cells. It offered a new try in the aspect of labeling cells by the embedded dyes. (C) 2008 Elsevier Ltd. All rights reserved.
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