Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 16, Pages 6015-6019Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.06.046
Keywords
Cyclodextrin; MTT assay; Fluorescence; Staining; Rhodamine dyes
Funding
- Grants-in-Aid for Scientific Research [20200037] Funding Source: KAKEN
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Two kinds of rhodamine modified beta-cyclodextrins (R-1 and R-2), which are coupled up ethylene diamine (EDA) and tetraethylene pentamine (TEPA) between Rh B and beta-cyclodextrin, respectively, have been synthesized. R-1 and 2 work as a new fluorogenic probe for monitoring pH of Hela cells, and MTT of assay R-1, R-2, and rhodamine B indicate that less a cytotoxicity of those R-1 and R-2 than that of rhodamine B, where R-1 has much less one than that of R-2. The fluorogenetic probe capability of R-2 was recognized in an area of acidic area in living cell, which is lysosome. (C) 2009 Elsevier Ltd. All rights reserved.
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