Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 9, Pages 3394-3398Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.03.038
Keywords
Oxidative decarboxylation; Periodate; Metalloporphyrin; Polystyrene
Funding
- center of Excellence of Chemistry of University of Isfahan (CECUI)
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In this report, highly efficient oxidative decarboxylation of carboxylic acids with sodium periodate catalyzed by a supported manganese(III) porphyrin is described. In the presence of manganese( III) tetra(4-pyridyl) porphyrin supported on cross-linked chloromethylated polystyrene, [Mn(T4PyP)-CMP], as catalyst, carboxylic acids were converted to their corresponding carbonyl compounds via oxidative decarboxylation with sodium periodate using imidazole as axial ligand. The oxidation of anti-inflammatory drugs such Indomethacin and Ibuprofen was carried out successfully and the decarboxylated products were obtained. This catalyst can be reused several times without loss of its catalytic activity in the oxidation reactions. (C) 2009 Elsevier Ltd. All rights reserved.
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