Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 2, Pages 606-613Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.11.066
Keywords
Pestalotiopsis fici; Pestalofones; Anti-HIV-1; Antifungal; Cyclohexanone
Funding
- National Basic Research Project of China [2009CB522302]
- National Project of Science and Technology of China [2008BAI63B01]
- Key Project of Hi-Tech Research and Development of China [2007AA021506]
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Pestalofones A-E (1-5), five new cyclohexanone derivatives, have been isolated from cultures of the plant endophytic fungus Pestalotiopsis. fici, along with the known compounds, isosulochrin (6), isosulochrin dehydrate (7), and iso-A82775C (8). The structures of 1-5 were determined by NMR spectroscopy, and the absolute configuration of 1 was assigned using the modified Mosher method. Compounds 1, 2, and 5 displayed inhibitory effects on HIV-1 replication in C8166 cells, whereas 3 and 5 showed significant antifungal activity against Aspergillus fumigatus. (C) 2008 Elsevier Ltd. All rights reserved.
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