Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 4, Pages 1422-1427Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.01.028
Keywords
Siphonodictyals; Terpenes; Phenols; Quinones
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Synthesis of protected siphonodictyal C was achieved via drim-7-en-11-al. Some sesquiterpene quinones and hydroquinones were tested for their pharmacological activities in assays in search of antiproliferative, cytotoxic, antiphlogistic, antirheumatic and anti-inflammatory drugs. Wiedendiol B is a ten times stronger cyclooxygenase-2 inhibitor than the reference compound indomethacine. Cyclooxygenase-2 inhibitors are drugs with antiphlogistic and antirheumatic activity. (c) 2009 Elsevier Ltd. All rights reserved.
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