Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 13, Pages 4674-4680Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.04.064
Keywords
p-Terphenyls; Curtisians; Paxillus curtisii; Free radical scavengers; Fenton reaction
Funding
- Korean Government (MOEHRD) [KRF-2006-532-F00001]
- Rural Development Administration (RDA), Republic of Korea [20080401-034-069]
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New p-terphenyls, curtisians R (1)-V ( 5), have been isolated together with known compounds, curtisians E, I-P, and kynapcin-12, from the methanolic extract of the fruiting bodies of Paxillus curtisii (Paxillaceace). Their structures were established by various spectroscopic analyses including 1D- and 2D-NMR experiments, as well as high-resolution FAB-mass analysis. They exhibited significant protective effects against oxidative damage of supercoiled DNA and 2-deoxyribose by hydroxyl radicals generated from the Fenton reaction. (C) 2009 Elsevier Ltd. All rights reserved.
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