Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 3, Pages 1325-1338Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.12.017
Keywords
Artemisinin; Cancer; Dimer; Malaria
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A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity ( as low as 30 pM) versus Plasmodium falciparum and in vitro anticancer activity in the micromolar to nanomolar range versus HL-60 cell lines. (c) 2009 Elsevier Ltd. All rights reserved.
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