Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 17, Issue 22, Pages 7743-7748Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.09.040
Keywords
AIE; Silole; G-quadruplex; Visual observation
Funding
- National Science Fund of China (NSFC) [90813031]
- National Science Fund for Distinguished Young Scholars [20425206]
- Cultivation Fund of the Key Scientific and Technical Innovation Project
- Ministry of Education of China [706040]
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AIE molecule silole 1 could be used to detect G-quadruplex formation using an exonuclease I hydrolysis assay. This visual observation of G-quadruplexes has been successfully used in investigating multiple G-quadruplexes, including the one-stranded telomeric, c-myc, c-kit, VEGF G-quadruplexes, and a d(G(4)T(4)G(4)) inter-molecular G-quadruplex. The detection of G-quadruplex can be also applied to G-quadruplex isomers induced by small molecules. (C) 2009 Elsevier Ltd. All rights reserved.
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