Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 22, Pages 9790-9794Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.09.064
Keywords
Chalcone; 4-Hydroxy-derricin; Antibacterial activity; Bacteria; Minimal inhibitory concentration; Minimal bactericidal concentration
Funding
- Fundacao de Apoio a Pesquisa Cientifica e Tecnologica do Estado de Santa Catarina (FAPESC)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
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The antibacterial activity of 31 chalcones was tested against bacterial strains, Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus ATCC 25923. Some of the tested chalcones showed fair to significant activity against Gram-positive bacteria. By comparison of the results obtained, the antibacterial activity can be related to features such as the presence of a C-4 hydroxyl group, a C-4' oxygenated substituent or a C-3' isoprenoid side chain, while the C-2' hydroxyl group might have importance for the stability of the molecule. The inhibitory effect of chalcones on human pathogenic microorganisms can be correlated with the substitution patterns of the aromatics rings. (C) 2008 Elsevier Ltd. All rights reserved.
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