☆ 4.7 Article

Hetero-Diels-Alder reaction of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with arylsulfonylcyanides. Synthesis and antimicrobial activity of 4-hydroxy-2-(arylsulfonyl)pyridines

BIOORGANIC & MEDICINAL CHEMISTRY (2008)

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Journal

BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 23, Pages 9898-9903

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.10.033

Keywords

Antimicrobial activity; Cyclizations; Pyridines; Silyl enol ethers

Categories

Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic

Funding

  1. state of Pakistan
  2. HEC

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Hetero-Diels-Alder reactions of 1,3-bis(silyloxy)-1,3-butadienes with arylsulfonylcyanides afforded a variety of 4-hydroxy-2-(arylsulfonyl) pyridines. Several derivatives show antimicrobial activity against Gram-positive bacteria. (c) 2008 Elsevier Ltd. All rights reserved.

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