Nosocomial COVID-19 Incidence and Secondary Attack Rates among Patients of Tertiary Care Center, Zurich, Switzerland

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Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020-October 2021

Eero Poukka et al.

Summary: Recently, the effectiveness of Covid-19 vaccines, especially against mild disease, has decreased due to the emergence of the Delta variant and waning protection. A register-based study in Finland found that the vaccine effectiveness of two-dose mRNA vaccine series against SARS-CoV-2 infection decreased from 82% to 53% after 6 months. Similar trends were observed for other vaccine series. Waning protection was not observed against Covid-19 hospitalization. These results inform decision-making regarding booster doses for healthcare workers.

VACCINE (2022)

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Article Immunology

Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost

Jingwen Ai et al.

Summary: This study explored the immunogenicity of different vaccination strategies against the Omicron variant of SARS-CoV-2. The results showed that the Omicron variant has a high immune escape ability compared to other variants, but heterologous protein subunit vaccines and homologous inactivated vaccine boosters can improve neutralization against Omicron.

EMERGING MICROBES & INFECTIONS (2022)

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Article Immunology

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron

Youchun Wang et al.

Summary: The Omicron variant shows greater potential for immune escape compared to other variants, suggesting a significant impact on immunity from previous infections and vaccines.

EMERGING MICROBES & INFECTIONS (2022)

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Article Immunology

Risk of Healthcare-Associated Transmission of Sever Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Hospitalized Cancer Patients

Karin Chow et al.

Summary: The risk of hospital-acquired COVID-19 is low for high-risk hospitalized patients, especially during periods of low community prevalence. However, shared occupancy with an infected patient can lead to a high secondary infection rate in roommates. Routine testing is unnecessary when community rates are low.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Immunology

The Risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission from Patients With Undiagnosed Coronavirus Disease 2019 (COVID-19) to Roommates in a Large Academic Medical Center

Abraar Karan et al.

Summary: This study assessed the transmission of SARS-CoV-2 virus between patients in shared rooms in an academic hospital. The results showed that out of 11,290 patients, 25 tested positive. Among 31 roommates exposed to the virus, 12 tested positive within 14 days. The study also found an association between transmission and PCR cycle thresholds <= 21.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Public, Environmental & Occupational Health

Coronavirus disease 2019 (COVID-19) incidence after exposures in shared patient rooms in a tertiary-care center in Iowa, July 2020-May 2021

Alexandra M. Trannel et al.

Summary: The incidence of SARS-CoV-2 exposure in shared patient rooms was low at our institution, but the secondary attack rate was comparable to that seen in household exposures. Longer exposures were associated with SARS-CoV-2 conversion. Hospitals should implement measures to decrease shared-room exposures.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2022)

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Letter Immunology

Identifying Contact Risks for SARS-CoV-2 Transmission to Healthcare Workers during Outbreak on COVID-19 Ward br

Marius Zeeb et al.

EMERGING INFECTIOUS DISEASES (2022)

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Article Immunology

Nosocomial Transmission of Coronavirus Disease 2019: A Retrospective Study of 66 Hospital-acquired Cases in a London Teaching Hospital

Hannah M. Rickman et al.

Summary: COVID-19 can lead to deadly healthcare-associated outbreaks, with 15% of inpatients in a major London teaching hospital being confirmed or probable hospital-acquired cases. Despite a 36% case fatality rate, nosocomial infection rates decreased after comprehensive infection prevention and control measures were implemented.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Immunology

The Household Secondary Attack Rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Rapid Review

Hannah F. Fung et al.

Summary: The study found that the household secondary attack rate of SARS-CoV-2 was 17.1%, with potential underestimation if only single follow-up tests were conducted. Testing household contacts multiple times could increase the yield for identifying secondary cases, especially among older adult contacts and contacts of symptomatic cases.

CLINICAL INFECTIOUS DISEASES (2021)

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Editorial Material Medicine, General & Internal

Ten scientific reasons in support of airborne transmission of SARS-CoV-2

Trisha Greenhalgh et al.

LANCET (2021)

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Article Public, Environmental & Occupational Health

Impact of In-Hospital infection with SARS-CoV-2 among Inpatients at a university hospital

Josni Tauffer et al.

Summary: The study evaluated the incidence of nosocomial infection and cross-transmission of SARS-CoV-2 among inpatients at a tertiary care teaching hospital. Despite preventive measures, nosocomial transmission occurred, especially in cardiac surgery wards, and precautions should be intensified during periods of high community transmission.

AMERICAN JOURNAL OF INFECTION CONTROL (2021)

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Article Surgery

Nosocomial infection with SARS-Cov-2 within Departments of Digestive Surgery

M. Luong-Nguyen et al.

JOURNAL OF VISCERAL SURGERY (2020)

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Article Public, Environmental & Occupational Health

Nosocomial COVID-19: experience from a large acute NHS Trust in South-West London

J. Taylor et al.

JOURNAL OF HOSPITAL INFECTION (2020)

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Nosocomial COVID-19 Incidence and Secondary Attack Rates among Patients of Tertiary Care Center, Zurich, Switzerland

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