Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 10, Pages 5619-5623Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.03.076
Keywords
Hypericum pseudopetiolatum var. kiusianum; phloroglucinol derivatives; petiolins A-C
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Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A ( 1) and B ( 2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C ( 3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C ( 3) exhibited antifungal activity. (C) 2008 Elsevier Ltd. All rights reserved.
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