Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 16, Pages 7561-7564Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.07.028
Keywords
marine sponge; sesquiterpenoid quinones; nakijiquinones G-I
Funding
- Uehara Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Three new sesquiterpenoid quinones, nakijiquinones G-I (1-3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1-3 were elucidated on the basis of the spectral data. Nakijiquinones G-I (1-3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity. (C) 2008 Elsevier Ltd. All rights reserved.
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