Journal
CELL REPORTS PHYSICAL SCIENCE
Volume 3, Issue 7, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.xcrp.2022.100962
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Funding
- National Key R&D Program of China [2018YFA0703200]
- National Natural Science Foundation of China [61890940, 51903051]
- Natural Science Foundation of Shanghai [19ZR1404400]
- Post doctoral Science Foundation of China [2020M670968, 2020M681166]
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This study presents a flexible biohybrid artificial motor biofeedback inspired by neuromuscular transmission, which may provide a way for nerve repair and development of neural prosthetics, as well as facilitate human-machine interfaces.
The simulation of neurotransmitter transmission in the biological nervous system holds great potential for the next generation of implantable neurological devices. Two challenges are (1) the fabri-cation of synaptic devices with selectivity to neurotransmitters in artificial reflex arcs and (2) the direct construction of biocompatible interfaces between biological tissues and devices to form biofeed-back. Herein, we report the construction of a flexible biohybrid artificial motor biofeedback inspired by neuromuscular transmission of acetylcholine (ACh). Biocompatible interfaces are built by seed-ing biological cells on the gate of the organic synapse. The ACh secreted from rat adrenal pheochromocytoma (PC-12) cells is con-verted by the organic synapse into electrical signals to modulate the excitatory postsynaptic currents (EPSCs) to drive the soft actu-ator. This reflex arc enables memory consolidation on exposure to ACh, exhibiting both short-term plasticity and specificity. This method may provide a way for nerve repair and development of neural prosthetics and facilitate human-machine interfaces.
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