Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 2, Pages 601-635Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.10.018
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The synthesis of pharmaceutically active compounds bearing a disubstituted piperidine framework is reviewed. Due to their frequent Occurrence in pharmaceutical research, functionalized piperidines and the synthetic methodologies used for their preparation are of considerable topical interest. The present review focuses on the synthetic pathways used for the preparation of disubstituted piperidines and also briefly covers the activity and/or usage of the same. (c) 2007 Elsevier Ltd. All rights reserved.
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