Related references
Note: Only part of the references are listed.
Article
Chemistry, Multidisciplinary
Jianhui Liu et al.
Summary: This study demonstrates the enrichment, recruitment, and release of multifaceted cargoes using a minimalist artificial membraneless organelle (AMLO) driven by liquid-liquid phase separation. The AMLO shows up to 10(5)-fold enrichment of cargoes, and recruitment and release can be triggered by variations in temperature, pH, and ionic strength. Additionally, the study achieves effective and reversible control of aggregation-induced emission, making the AMLO a versatile platform for potential drug delivery and biosensor applications.
Article
Multidisciplinary Sciences
Khatcher O. Margossian et al.
Summary: This study demonstrates the formation of a polyzwitterionic complex, which can serve as a potential drug delivery platform under physiological low pH conditions. The authors provide a mechanism for the assembly of such complexes and show their viability for pH-triggered release of cargo using simulation and experimental evidence.
NATURE COMMUNICATIONS
(2022)
Article
Polymer Science
Jianhui Liu et al.
Summary: Liquid-liquid phase separation (LLPS) is a fundamental mechanism for the organization of biological tissues, specifically the formation of membraneless organelles (MLOs). This study investigated the effect of nucleic acids on an artificial membraneless organelles (AMLO), and found that both DNA and RNA can enhance the LLPS of AMLO, with DNA having a higher tendency to solidify and decrease its dynamics.
Article
Chemistry, Multidisciplinary
Jianhui Liu et al.
Summary: Researchers have designed synthetic hybrids that mimic the characteristics of membraneless organelles by combining short oligopeptides and dextran. These hybrids undergo liquid-liquid phase separation, forming micron-sized liquid droplets. The droplets can recruit other biomolecules and provide a favorable environment for biochemical reactions, similar to natural membraneless organelles.
ACS CENTRAL SCIENCE
(2022)
Review
Materials Science, Multidisciplinary
Jianhui Liu et al.
Summary: Membraneless organelles (MLOs) are phase-separated liquid compartments in cells that provide precise control over biomolecules and metabolism. Their formation relies on weak non-covalent interactions of intrinsically disordered proteins (IDPs). Understanding the design and behavior of IDPs in liquid-liquid phase separation is crucial for understanding the contributions of MLOs to cellular physiology and disease. This knowledge can also inspire the design of biomaterials and systems in various fields.
Article
Chemistry, Multidisciplinary
Jianhui Liu et al.
Summary: By leveraging complex coacervation and aggregation-induced emission characteristics, we achieved eight basic logic operations with environmental stimuli as inputs, generating Boolean-like fluorescence intensity or turbidity outputs with a contrast higher than one order of magnitude. Additionally, we demonstrated the storage of information in a fluorescent pattern and thermo-sensor applications.
MATERIALS HORIZONS
(2022)
Review
Chemistry, Physical
N. Amy Yewdall et al.
Summary: Coacervates are condensed liquid-like droplets formed by oppositely charged polymeric molecules, with remarkable material properties that have been extensively studied. They play an important role in the formation of membraneless organelles in living cells. Well-characterized coacervates can serve as useful models to better understand specific aspects of membraneless organelles.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Article
Chemistry, Applied
Zipei Zhang et al.
Summary: Biopolymer microgels were designed to encapsulate and protect probiotics before releasing them in the colon. Encapsulation greatly improved probiotics' stability, with different formulations showing varying degrees of effectiveness under simulated gastrointestinal conditions. Further studies using in vivo models are required to validate these findings.
FOOD HYDROCOLLOIDS
(2021)
Review
Multidisciplinary Sciences
Yongdae Shin et al.
Article
Chemistry, Multidisciplinary
Andrew J. Keefe et al.
