Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 117, Issue 1, Pages 9-19Publisher
WILEY-BLACKWELL
DOI: 10.1002/jcb.25280
Keywords
CTs; NUCLEUS; INTERPHASE
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Funding
- National Institutes of Health [P01 CA082834]
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The organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of increasingly sophisticated microscopic and molecular techniques, now provide complementary strategies for studying CTs in greater depth than ever before. Here we provide an overview of these strategies and how they are being used to elucidate CT interactions and the role of these dynamically regulated, nuclear-structure building blocks in directly supporting nuclear function in a physiologically responsive manner. (C) 2015 Wiley Periodicals, Inc.
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