Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 10, Pages 5570-5583Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.04.003
Keywords
anti-proliferative activity; carbohydrates; N-heterocycles; indirubin
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The first indirubin-N'-glycosides were prepared based on reactions of isatin-N'-glycosides with indoxyls. The products show a significant anti-proliferative activity against various human cancer cell lines. Good results were observed for an indirubin-N'- mannoside which was shown to have medium to high anti-proliferative activity against all investigated cell lines. The highest activities and selectivities against the MCF-7 breast cancer cell line were observed for indirubin-N'-rhamnosides. (C) 2008 Elsevier Ltd. All rights reserved.
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