Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 19, Pages 8896-8906Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.08.060
Keywords
cytokines; alpha-galactosylceramides; NKT cell; OCH; sulfonamide
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [20790108]
- Grants-in-Aid for Scientific Research [20790108] Funding Source: KAKEN
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RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 (1) with a sulfonamide linkage instead of an amide bond, were synthesized to examine their bioactivity for mouse natural killer (NK) T cells. RCAI-17, 22, 24-26, 29, 31, 34-36, and 88 are the aromatic sulfonamide analogs, while RCAI-39 and 40 are the aliphatic ones. RCAI-38 is a C-galactoside analog of RCAI-26, which is the p-toluenesulfonamide analog of KRN7000. According to their bioassay, these sulfonamide analogs were shown to be the stimulants of mouse NKT cells to induce the production of Th2-biased cytokines in vitro, while RCAI-38 did not induce any cytokine production. (C) 2008 Elsevier Ltd. All rights reserved.
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